In conclusion, this study innovatively combined the results of three important metabolic tissues, adipose tissue, liver tissue and skeletal muscle, performed integrative bioinformatic analyses to analyse the potential immune and inflammatory mechanisms of BS, and revealed the hub genes (TYROBP, TLR8, FGR, NCF2, HCK, CCL2, LAPTM5, MNDA and S100A9) associated with changes in immune cell infiltration after BS. Here, S100A9 is linked to Bloom syndrome.