ABC294640 also promoted a reduction in productive infection in both biological sexes (33.75% inhibition in males, standard deviation 20.87; 36.0% inhibition in females, standard deviation 14.27), yet in some donors this was observed concomitantly with reduced viability, suggesting that SPHK2 inhibition in the 20 to 40 μM range either promoted death of infected cells or reduced viability overall (Fig. 4G and H). Here, SPHK2 is linked to infection.