SPHK2 and infection: In contrast, the lack of alteration of pSAMHD1 via targeting SPHK2 with ABC294640 compared to the reduction observed with genome editing supports our data demonstrating that ABC294640 does not reduce the susceptibility of target cells to infection by a panel of HIV-1 primary isolates and molecular clones as FTY720, DMS, and SKI II do in pretreatment experiments (Fig. 3).