Monoclonal antibodies (mAbs) targeting the SARS-CoV-2 spike (S) glycoprotein (1) have been an effective treatment for improving outcomes for patients with coronavirus disease 2019 (COVID-19) (2–5), but many are sensitive to viral escape through point mutations in their epitopes on the S trimer (6, 7), and producing mAbs in sufficient quantities for population scale use during a global pandemic is technically and financially challenging (8). The gene discussed is ART4; the disease is COVID-19.