However, the data obtained agree with the following working hypothesis concerning obesity-related hyper-androgenemia: in some obese peri-pubertal girls, excessive IGF-1 and insulin act in synergy with ACTH and LH to stimulate the production of androgens from adrenocortical cells and ovarian theca cells respectively [7]. Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.