Table 1 shows and compares the mean values for the clinical characteristics (age and BMI-SDS) and hormonal determinations (leptin, TSH, FT4, IGF-1, PL, insulin and HOMA-IR) in prepubertal and early-puberty subgroups according to BMI status (control and obesity groups). This evidence concerns the gene LEP and obesity due to melanocortin 4 receptor deficiency.