INS and obesity due to melanocortin 4 receptor deficiency: In prepubertal subgroup, girls with obesity had significantly higher values (p < 0.05) for BMI-SDS, leptin and insulin levels, and HOMA-IR index than control group, and there were no significant differences in age, TSH, FT4, IGF-1, IGFBP3, and PL levels among both groups.