In early-puberty subgroup, girls with obesity had significantly higher values (p < 0.05) for LH, ACTH, androstendiona, T and FT levels than control group, and there were no significant differences in age, FSH, estradiol, cortisol and 17-OH-P levels among both groups. This evidence concerns the gene BRD2 and obesity due to melanocortin 4 receptor deficiency.