INS and obesity due to melanocortin 4 receptor deficiency: In early-puberty subgroup, girls with obesity had significantly higher values (p < 0.05) for BMI-SDS, leptin, IGF-1, IGFBP· and insulin levels, and HOMA-IR index than control group, and there were no significant differences in age, TSH, FT4 and PL levels among both groups.