Notwithstanding the large amount of research conducted on the roles of CatB in the pathological conditions, its proteolytic function can be divided into the following categories: (1) trigger inflammation by activating the inflammatory switch in myeloid cells; (2) degrade the extracellular matrix (ECM), thereby facilitating the invasive potential of tumor cells; (3) promote the production of vital pathological molecules by activating specific substrates. This evidence concerns the gene TYRP1 and neoplasm.