Population level genome‐ and exome‐wide association studies have identified several common variants implicated in the severity of NAFLD.[5] p.Ile148Met in patatin‐like phospholipase domain‐containing protein 3 (PNPLA3) is the variant most strongly associated with increased severity of NAFLD[6, 7] and has been well studied, leading to its identification as a lipid droplet‐binding protein that influences the recruitment of hydrolyzing enzymes.[8, 9]. Here, PNPLA3 is linked to metabolic dysfunction-associated steatotic liver disease.