HSD17B13 and metabolic dysfunction-associated steatohepatitis: The splice variant rs72613567T>TA in HSD17B13 has been consistently associated with a lower grade of lobular inflammation, NASH, and stage of fibrosis in adults,[10] although without any difference in severity of histologic steatosis.[16, 33] In children, we observed a strong negative association with grade of periportal inflammation with no effect on lobular inflammation.