STAT3 and neoplasm: Previous results have shown that Stat3 induces anti-apoptotic genes such as bcl-xL, mcl-1, and survivin [4, 30, 31], it downregulates the p53 promoter [3], while it can affect the cellular metabolism through its ser727-phosphorylated form, in a way that it protects tumor cells from apoptosis further [32–34].