F8 and hemophilia A: In dogs with hemophilia A that demonstrated persistent liver-derived FVIII expression and correction of bleeding phenotype for >10 years following AAV-canine-FVIII-SQ gene transfer, <5% of remaining detected vector DNA was integrated in dog liver genomes41; the same study showed that plasma FVIII activity was associated with hepatocyte levels of full-length episomes17,42.