To understand whether the antigen drive is restricted to T-LGLL, we performed a similar analysis using TCRβ-seq samples from patients with RA32 (n = 45), metastatic melanoma sampled from blood33 (SKCM, n = 29), and healthy controls (CD8+ sorted32, n = 38; MNC-sorted n = 78534) (Supplementary Data 1) with similar subsampling. The gene discussed is CD8A; the disease is metastatic melanoma.