Flow cytometry analysis also confirmed that although the total number of monocytes was reduced (P < 0.05, Mann-Whitney test), the distribution of different monocyte subsets was altered, and T-LGLL patients had a bigger proportion of CD16+ cells (P < 0.05, Supplementary Fig. 16a, b) out of the CD14+ monocytes. This evidence concerns the gene FCGR3A and T-cell large granular lymphocyte leukemia.