Flow cytometry analysis also confirmed that although the total number of monocytes was reduced (P < 0.05, Mann-Whitney test), the distribution of different monocyte subsets was altered, and T-LGLL patients had a bigger proportion of CD16+ cells (P < 0.05, Supplementary Fig. 16a, b) out of the CD14+ monocytes. The gene discussed is CD14; the disease is T-cell large granular lymphocyte leukemia.