For example, the expression of different cytokines (CCL2/3/4/5), co-stimulatory genes (CD27, TNFRSF4 [HVEM], TNFRSF14 [OX40], TNFRSF25 [DR3]), and IFNγ response genes (e.g., B2M, TAP1, HLA molecules) were upregulated in different non-leukemic NK-cells, monocytes, and B-cell clusters in comparison with healthy controls (Fig. 5a), other cancers (Supplementary Fig. 14a), and patients with blood cancers (Supplementary Fig 14b, Supplementary Data 2). The gene discussed is B2M; the disease is cancer.