STAT3 and T-cell large granular lymphocyte leukemia: Although the patient had no treatment for her T-LGLL disease, the dominant STAT3 mutated clone (78% → 10%) which was not antigen-driven, was replaced by an antigen-driven STAT3 wild-type clone (5% → 24%) carrying a different TCRαβ (Fig. 3e, f, Supplementary Fig. 11a–e).