The inhibitory effects of SLC25A38 on angiogenesis we found were based on the suppression of transcriptional coactivator for HIF signaling pathway and HIF-1α protein level, and to our best knowledge, it is the first time to confirm the relationship between SLC25A38 and CBP/HIF-related tumor growth and metastasis. This evidence concerns the gene SLC25A38 and neoplasm.