GSDMD may regulate the cell cycle by suppressing the S to G2/M phase transition in gastric cancer cells through activation of the extracellular signal-regulated kinase (ERK), signal transducer and activator of transcription 3 (STAT3) and phosphatidylinositol 3 kinase/protein kinase B (PI3K/AKT) signaling pathways [82]. Here, STAT3 is linked to gastric cancer.