CD47 and other immunosuppressive molecules are overexpressed in glioblastoma multiforme (GBM) and could bind with their ligands expressed in macrophages, thereby exerting an inhibitory effect on innate and adaptive immune function and ultimately leading to immune escape in GBM [12], meanwhile the elevated expression of CD47 could promote GBM invasion and proliferation [13]. This evidence concerns the gene CD47 and glioblastoma.