Interestingly, inhibition of glioblastoma HA synthesis with 4-methylumbelliferone (4MU) also led to downregulation of CD47 expression in glioblastoma cells and upregulated SIRPα expression in macrophages, which further facilitated the phagocytosis of glioblastoma cells by macrophages. The gene discussed is SIRPA; the disease is glioblastoma.