Moreover, HAS3 knockdown in glioblastoma has the similar effects as 4MU, we observed that the expression of CD47 in glioblastoma could be suppressed by HAS3 knockdown and the expression level of SIRPα in macrophages induced by LV-shHAS3 CM was increased, in addition, these effects could be rescued by exogenous HA (Fig. 6E, F). Here, HAS3 is linked to glioblastoma.