The AT(N) framework proposes the use of biomarkers of Aβ (A), tau (T), and neurodegeneration (N) to classify individuals on the AD continuum.1 However, neurodegeneration is not specific to AD, and this study highlights that CVD, as represented by WMHs, has significant independent effects on neurodegeneration, which are potentially greater in magnitude than those of Aβ. The gene discussed is MAPT; the disease is Alzheimer disease.