APOE and hippocampal atrophy: APOE ε4 carriers had significantly greater rates of hippocampal atrophy (0.011 mL/y faster than noncarriers), and there were directionally consistent but nonsignificant relationships with rates of whole-brain atrophy (0.67 mL/y higher than noncarriers) and ventricular expansion (0.13 mL/y faster than noncarriers).