ARID1A and pancreatic neoplasm: To study the influence of this human enhancer on ARID1A expression, we deleted the hA.E4 enhancer in the hTERT-HPNE cell line, relevant for the pancreatic tumour suppressor role of ARID1A, through CRISPR-Cas9 system (Fig. 4d and Supplementary Fig. 5c–e), using a deletion in an unrelated genomic region16 as a control.