HEPHL1 and pancreatic agenesis: zP.E3 interacts with the promoter of ptf1a, observed by Hi-ChIP and 4C-seq (Fig. 5a and Supplementary Fig. 5b), and could correspond to the functional equivalent enhancer whose deletion causes pancreatic agenesis in humans (hP.E3), although its sequence partially aligns with a more distal human sequence likely inactive in human pancreatic cells (Supplementary Fig. 6).