Among these SRC activating CAS proteins, NEDD9 (alternatively designated HEF1 or CAS-L) is notable because it is strongly upregulated during tumor progression [14, 15], promoting invasion and metastasis by stimulating SRC and FAK phosphorylation of substrates that promote cytoskeletal rearrangement, cell migration, and survival signaling [16]. This evidence concerns the gene NEDD9 and neoplasm.