KRAS and non-small cell lung carcinoma: To complement studies of consequences of transient depletion of NEDD9 for expression of effectors and glycolytic pathway enzymes, we also examined their expression in biological specimens from NSCLC tumors that formed in mice with inducible, lung-specific activation of Kras and loss of Trp53 (Krastm4Tyj/J/Trp53tm1Brn/J [23, 24] mice) with a wild type versus a null allele for Nedd9 [25] (KP versus KPN mice) (Fig. 3, S4).