We identified that these were enriched in several pathways including “molecular mechanisms of cancer” (p = 9.82 × 10−9), “GNRH signaling” (p = 6.51 × 10−6), “TGF-Signaling” (p = 6.56 × 10−6), “Thrombin Signaling” (p = 7.04 × 10−6) and “RhoGDI Signaling” (p = 1.72 × 10−5) (Additional file 1: Figure S2 and Additional file 2: Table S4A). This evidence concerns the gene ARHGDIA and cancer.