Additionally, we identified notable differentially methylated gene promoters, including GZMA (15% hypomethylated in NEC) [16], LTB4R (14.6% hypomethylated in NEC) [17], ISG20 (14.6% hypomethylated in NEC) [18], PLCB2 (12.7% hypomethylated in NEC) [19], VDR (12% hypomethylated in NEC) [20], TNIP1 [21] (19% hypermethylated in NEC) and GALNT6 [22] (22% hypermethylated in NEC). The gene discussed is ISG20; the disease is necrotizing enterocolitis.