Phospholipase C Beta 2 (PLCB2), which is involved in epithelial repair and integrity in the intestine [19], was also hypomethylated in its promoter region in NEC, as well as the vitamin D receptor (VDR), which protects against intestinal injury of NEC partly through suppressing the expression of the innate immune receptor, toll-like receptor 4 (TLR4) [20]. This evidence concerns the gene TLR4 and necrotizing enterocolitis.