We compared expression levels of phototransduction-related genes, OPN1SW (the blue opsin gene), SAG (the S-antigen gene), RCVRN (the recoverin gene), RHO (the rhodopsin gene), GNAT1 and GNAT2. From one to six weeks after CNRO gene transduction, expression levels of the blue opsin gene, the recoverin gene and the GNAT1 gene were lower in photoreceptor-directed fibroblasts derived from EYS-RP patients (Fig. 1). The gene discussed is SAG; the disease is retinitis pigmentosa 1.