ALOX5AP and arthritic joint disease: Although many studies have shown that inhibition of FLAP can significantly improve ischemic myocardial infarction [45], asthma [46], arthritis [47], breast cancer [23], lung cancer [25], and other diseases, the results of this study showed that FLAP can promote apoptosis of HepG2 cells and inhibit migration and proliferation of HepG2 cells.