A priori, this observation may appear conflictual with the reduction of PACE4 splicing observed following ERG overexpression in PCa cells (Fig. 1B,C) however, considering the very high level of exogenous ERG expression required for the slight (roughly 20%) reduction, this suggest the lack of direct causality between PACE4-altCT genesis and ERG expression in PCa tumors. Here, PCSK6 is linked to posterior cortical atrophy.