PTEN and prostate adenocarcinoma: In the succession of events leading to prostate adenocarcinoma development, one of the two most important cellular events, along with the loss of phosphatase and tensin homolog (PTEN) gene, is the genomic rearrangement leading to the fusion between transmembrane protease serine 2 (TMPRSS2) with the v-ets erythroblastosis virus E26 oncogene homolog (ERG), also termed TMPRSS2:ERG, which occurs in 50–60% of PCa tumors8–10.