Effective tumor infiltrating lymphocytes (TILs) activate Th1-associated pathways such as the interferon-γ/Janus kinase/signal transducer and activator of transcription 1 (IFN-γ/JAK/STAT1)–mediated signaling pathway, which leads to increased expression of immune checkpoints on tumor cells [9]. The gene discussed is STAT1; the disease is neoplasm.