External insults, such as environmental insults (e.g., asbestos), autoimmune diseases (e.g., lupus erythematosus) and drugs [e.g., bleomycin (BLM)], can cause the disturbed production of pro-fibrotic mediators, including connective tissue growth factor (CTGF), transforming growth factor-β1 (TGF-β1) and platelet derived growth factor (PDGF) [2–5]. The gene discussed is CCN2; the disease is autoimmune disease.