Overall, the analysis revealed that all five genetic models (allelic, dominant, recessive, homozygous, and heterozygous models) of the IL-17A rs2275913 polymorphism were related to an elevated colorectal cancer risk (A vs. G: OR = 1.59, 95% CI = 1.34–1.89, P < 0.001; AA/AG vs. GG: OR = 1.75, 95% CI = 1.36–2.25, P < 0.001; AA vs. GG/AG: OR = 1.74, 95% CI = 1.41–2.15, P < 0.001; AA vs. GG: OR = 2.05, 95% CI = 1.62–2.60, P < 0.001; AG vs. GG: OR = 1.60, 95% CI = 1.23–2.09, P = 0.001) (Table 3). Here, IL17A is linked to colorectal cancer.