The overall analysis results revealed highly significantly positive associations between the IL-17A rs2275913 polymorphism and colorectal cancer in all five genetic models (A vs. G, AA/AG vs. GG, AA vs. AG/GG, AA vs. GG, and AG vs. GG), suggesting that this mutation may be a remarkable genetic risk factor in the tumorigenesis of colorectal cancer. The gene discussed is IL17A; the disease is colorectal cancer.