IL17A and juvenile idiopathic arthritis: IL-17A blockade with the research-use-only antibody as well as in vitro inhibition of IL-17A by Secukinumab resulted in steady and almost equal inhibition of PBMC proliferation compared to positive control in both JIA (50.0% vs. 52.5%; p = 1.00) and HC (59.1% vs. 60.5%; p = 0.534) (Fig. 2).