VANGL1 and colorectal carcinoma: Although some studies found that PKCδ mRNA expression was decreased in most primary CRC tumors and some CRC cell lines, the p-PKCδ level was increased in a subset of colorectal cancers, and this increase can also enhance the migration and invasiveness of colon carcinoma cells by enhancing KITENIN expression and phosphorylation of HuR and Trop-2 [26, 27, 36].