In this long course, several factors such as DNA damage [20] and mutation in TP53 tumor suppressant gene, immune cells, and cytokines produced by them, signaling pathways such as NFκB, STAT3, AKT/PI3K [21], and WNT/β-Catenin [22] are involved and miRNAs are also associated with all of these factors in some way. The gene discussed is TP53; the disease is neoplasm.