There is also a region on mouse chromosome 1, which is also part of our test set, whose mouse ortholog is an OCR and macaque ortholog is not an OCR according to our data and predictions despite being highly conserved (Fig. 4d) and whose mouse and macaque orthologs are near Fn1. This gene has been implicated in liver fibrosis [89–91], and a multi-species liver RNA-seq study found that it has higher expression in mouse liver relative to livers of other mammals and birds and lower expression in primate livers relative to livers of other mammals and birds [92]. The gene discussed is FN1; the disease is Hepatic fibrosis.