LNPK and neurodevelopmental disorder: In addition, there is a region on mouse chromosome 2 that has high mean sequence conservation but low experimentally identified and predicted open chromatin conservation between mouse and macaque (Fig. 4b) and whose mouse and macaque orthologs are located near the gene Lnpk. This gene is an endoplasmic reticulum junction stabilizer [81] that has been shown to play a role in brain and limb development [82], and mutations in this gene have been associated with neurodevelopmental disorders [83].