SPIN1 and early-onset autosomal dominant Alzheimer disease: This OCR’s mouse and macaque orthologs are located near the gene Stx16. STX16 is involved in vesicle trafficking in most tissues, including the brain [77], and may play a role in Alzheimer’s disease [78]; in fact, its role in axon regeneration is conserved between mammals and the roundworm C. elegans [79].