In addition, recent studies showed that mutations in ZFs 1 and 10 disrupt DNA loops [26, 27]; another recent study showed that CTCF-s, a CTCF isoform that does not have ZFs 1–3, is unable to interact with cohesin [28]; and an additional recent study showed that mutations in CTCF’s ZFs have been found in cancer and that some, including a mutation in ZF 2, lead to a loss of binding [29]. This evidence concerns the gene CTCF and cancer.