IL1B and amyotrophic lateral sclerosis: Lu CH et al. found that in ALS patients, the levels of TNF-α, IL-1β, IL-2, IL-8, IL-12, IL-4, IL-5, and IL-10 were significantly higher than those of the control group, suggesting that most inflammatory factors of the T-cell immune response may be involved in the pathogenesis of ALS [29].