As shown in some studies related to kidney function and As, carriers with the A allele of this SNP may show different expressions of the TNF gene, resulting in more susceptibility to skin lesions, eye and respiratory diseases induced by chronic arsenic exposure [23]; higher multiple organ failure (MOF score) assessments in patients with acute kidney injury and acute pancreatitis [19]; and higher contrast-induced nephropathy [OR = 2.11 (1.08–4.09), p = 0.025]. The gene discussed is TNF; the disease is Multiple Organ Failure.