ACE and hypertensive disorder: Search keywords were the following: fixed-dose combination; single-pill combination; polytherapy of hypertension; hypertension treatment; hypertension; combination antihypertensive therapy; antihypertensive drugs; β-adrenergic receptors blockers; beta-blocker; angiotensin-converting enzyme inhibitors; ACE-I; beta-blockers and ACE-I combination; rationale of combining beta-blockers with ACE-I; and antihypertensive product overview.