Overexpression of TKTL1 has been associated with poor prognosis, invasivity, and metastasis and has been described in numerous cancer types including breast, lung, colonic, urothelial, esophageal, gastric, laryngeal cancer, melanoma, and oral squamous cell carcinomas (OSCC) and contributes to the development of a malignant phenotype via the stabilization and accumulation of HIF1α and increased aerobic glycolysis [18,19,20,21,22,23,24,25,26,27,28]. This evidence concerns the gene TKTL1 and melanoma.