ESR1 and neoplasm: BCSS did not differ significantly by smoking status (Figure 1) after adjustment for age, race, marital status, education, tumor stage, tumor characteristics (grade, type, size), node status, tumor hormone receptor statuses (HER2, ER, and PR), BMI, CCI, and site of enrollment, the HRs were 1.40 (95% CI, 1.04–1.88) and 1.59 (95% CI, 1.06–2.37) for former and current smokers for overall survival, and 1.44 (95% CI, 0.92–2.24) and 1.37 (95% CI, 0.79–2.40) for former and current smokers for BCSS, compared with non-smokers.