For example, the enrichment of TP53 mutations in breast tumors from smokers [3] may promote the basal-like subtype, which is characterized by high rates (80%) of TP53 mutations [4], while cigarette smoking has been reported to have anti-estrogenic effects [5], which may reduce the risk of estrogen receptor (ER) positive tumors. Here, TP53 is linked to breast neoplasm.