Our analysis revealed that (independent, of final treatment strategies—CABG + OMT, PCI + OMT, OMT) age, cardiogenic shock on admission, LV dysfunction (EF < 30 %), NYHA class III-IV, diabetes requiring insulin, PAD, CKD, anaemia, COPD, severe PH, cancer, frailty, LM disease, CTO and EuroSCORE II, were independent factors associated with increased occurrence of primary endpoint in long term follow-up (p = 0.02, <0.01, <0.01, 0.03, 0.04, 0.02, <0.01, <0.01, <0.01, <0.01, <0.01, <0.01, 0.03, 0.01, <0.01, respectively). The gene discussed is INS; the disease is diabetes mellitus.