Our analysis revealed that (independent, of final treatment strategies—CABG + OMT, PCI + OMT, OMT) age, cardiogenic shock on admission, LV dysfunction (EF < 30 %), NYHA class III-IV, diabetes requiring insulin, PAD, CKD, anaemia, COPD, severe PH, cancer, frailty, LM disease, CTO and EuroSCORE II, were independent factors associated with increased occurrence of primary endpoint in long term follow-up (p = 0.02, <0.01, <0.01, 0.03, 0.04, 0.02, <0.01, <0.01, <0.01, <0.01, <0.01, <0.01, 0.03, 0.01, <0.01, respectively). This evidence concerns the gene INS and cancer.