The working hypothesis (Figure 7) is that Marula leaf extract attenuates hepatic steatosis perhaps by impacting the epigenetic regulation of fatty acid oxidation (via the modulation of the association between Mthfr and Cpt1) and lipogenesis (through the repression of Fasn activity) genomic machineries; however, this link requires further investigation. This evidence concerns the gene FASN and fatty liver disease.