The working hypothesis (Figure 7) is that Marula leaf extract attenuates hepatic steatosis perhaps by impacting the epigenetic regulation of fatty acid oxidation (via the modulation of the association between Mthfr and Cpt1) and lipogenesis (through the repression of Fasn activity) genomic machineries; however, this link requires further investigation. The gene discussed is MTHFR; the disease is fatty liver disease.