However, the homozygous diabetic leptin-resistant BKS.Cg-Dock7m+/+ Leprdb/J (db/db) mice model used here has been a useful tool in studies of liver dysfunction, as the animals have previously been shown to exhibit hepatic steatosis and lobular inflammation, along with significantly elevated alanine transaminase, aspartate aminotransferase, total cholesterol and triglyceride levels as compared with non-diabetic mice [38,39]. Here, LEP is linked to fatty liver disease.