Substantial numbers of VEGF-C+ CD68+ CD163+ TAMs were distributed in the lesional skin of Merkel cell carcinoma [83], and expression of CD200 in tumor cells induces immunosuppressive CD163+ CD200R+ M2 TAMs and Foxp3+ Tregs to maintain the immunosuppressive tumor microenvironment [84]. This evidence concerns the gene VEGFC and Merkel cell skin cancer.