Since TAMs produce characteristic chemokines by the stimulation of specific stromal factors (e.g., periostin [POSTN], plasminogen activating inhibitor-1 (PAI-1), receptor activator of NF-κB ligand [RANKL]) [17,29,30], the correlations of chemokines derived from TAMs with stromal factors and profiles of TILs have been widely investigated in each cancer type [11]. The gene discussed is SERPINE1; the disease is cancer.