Since TAMs reside in the tumor sites in most of the skin cancers described above [18] and POSTN modulates TAM functions to induce proinflammatory cytokines and chemokines, as well as angiogenetic factors such as matrix metalloproteinase (MMP) [24,35,36,37,38,39,40], it is important to evaluate the expression levels of POSTN to predict tumor progression, and even predict the efficacy and immune-related adverse events (irAEs) in skin cancers [24,41]. This evidence concerns the gene POSTN and skin neoplasm.