In mycosis fungoides, CAFs derived from mycosis fungoides increased the expression of GATA3 (Th2 marker), as well as TWIFT1 and TOX (also used as a biomarker gene for the progression of mycosis fungoides), in CTCL cells [104] Overall, these reports suggest the possible mechanisms of crosstalk between tumor cells and CAFs in the development of the tumor microenvironment in non-melanoma skin cancers. Here, TOX is linked to neoplasm.