POSTN is involved in cell survival, angiogenesis, and metastasis in skin cancers [32] and is expressed in stromal surrounding tumor cells in various skin cancers, including melanoma [24,29,33,34], cutaneous squamous cell carcinoma (cSCC) [35,36], basal cell carcinoma (BCC) [37], dermatofibrosarcoma protuberans (DFSP) [38], Merkel cell carcinoma (MCC) [39], and mycosis fungoides [40]. The gene discussed is POSTN; the disease is skin squamous cell carcinoma.