Since these increased levels of TAM-related factors indicate the existence of anti-PD1 Abs in cancer stroma, these TAM-related factors could be useful biomarkers to predict anti-melanoma effects and onset of immune-related adverse events (irAEs) of anti-PD1 Abs in advanced cutaneous melanoma patients [24,25,26,27,28]. Here, PDCD1 is linked to melanoma.