In non-small-cell lung cancer cell lines [29], lncRNA PVT1 can bind to miR-424-5p to decrease the expression of factors in tumor progression, such as CRAM, MMP-2, MMP-9 and Bcl2, to inhibit growth and increase the expression of Bax, thus suppressing the development of tumor cells. The gene discussed is MMP2; the disease is neoplasm.