WEE1 and hepatocellular carcinoma: Some studies [50] have also found that downregulated DLX6-AS1, by targeting miR-424-5p, suppresses the expression of WEE1, which has been shown [21] to be a nuclear kinase that regulates the G2-M transition, and thus inhibition of WEE1 may be a potential targeted therapy for cancer by inhibiting the proliferation of HCC cells.