OTX1 and neoplasm: On the other hand, some studies have shown that the expression of miR-424-5p is downregulated in CRC, while its target gene human homeobox gene 1 (OTX1) is negatively correlated with miR-424-5p in colon cancer, and therefore the overexpression of miR-424-5p inhibits tumor proliferation and metastasis by downregulating OTX1.