MIEF2 and cancer: Recently, it has been shown [58] that the downregulation of miR-424-5p leads to the overexpression of MIEF2 (mitochondrial elongation factor 2) in OV tissues and cell lines, while the overexpression of MIEF2 significantly promotes the metabolic transition from oxidative phosphorylation to glycolysis in OV cells, and that the change in glucose metabolism characterized by increased glycolysis (also known as the Warburg effect) has been recognized as one of the markers of cancer [59] This leads to the occurrence, development and metastasis of tumors in OC.