Similarly, high levels of ALK protein in neuroblastoma (NB) are associated with metastatic NB cases and poor prognosis, while experimental results [66] have shown that miR-424-5p can directly target ALK receptors or indirectly regulate ALK expression in NB cells, resulting in a significant decrease in ALK protein and inhibition of cell viability in ALK-positive NB cell lines. The gene discussed is ALK; the disease is neuroblastoma.