VEGFA and infection: In fact, in an in vivo study on mice, it was found that, in the presence of meningitic Escherichia coli, the RSV interacting with the lipid raft of the endothelial cells of the blood–brain barrier, blocking the signal cascade of extracellular signal-regulated protein kinase 1/2 and vascular endothelial growth factor-A (ERK1/2-VEGFA), prevented penetration and, therefore, infection of the central nervous system (CNS) and reduced the production of inflammatory cytokines (Figure 3) [101,102].