These studies prompt some interesting observations with respect to potential roles for GPR37 and GPR37 L1 in ischemic stroke: (1) studies performing MCAO in Gpr37 l1-/- mice are needed to further understand this receptor’s contribution; (2) all stroke studies examining the functional relevance of GPR37 following MCAO have only been done using male mice and should be expanded to include female mice. Here, GPR37 is linked to ischemic stroke.