GPR37 and stroke disorder: These studies prompt some interesting observations with respect to potential roles for GPR37 and GPR37 L1 in ischemic stroke: (1) studies performing MCAO in Gpr37 l1-/- mice are needed to further understand this receptor’s contribution; (2) all stroke studies examining the functional relevance of GPR37 following MCAO have only been done using male mice and should be expanded to include female mice.