Canine DLBCL (cDLBCL) exhibits many characteristics similar to the activated B-cell (ABC) form of human DLBCL, including the constitutive activation of the nuclear factor-kB (NF-kB) pathway, the double expression of MYC proto-oncogene (MYC), and BCL2 apoptosis regulator, as well as the enrichment for genes in the MYC pathway [1,2,3]. The gene discussed is NFKB1; the disease is diffuse large B-cell lymphoma.