A recent article in human chronic lymphocytic leukaemia (CLL) found that regulatory elements acquired and lost as a result of epigenetic modifications were enriched for the binding sites of the well-established B-cell and CLL TFs NF-kB, AP2, P53, E2F1, PAX5 and SP1 [71]. The gene discussed is SP1; the disease is B-cell chronic lymphocytic leukemia.