In a mouse model of streptozotocin (STZ)-induced diabetes, changes in epidermal AQP3 expression have been invoked to explain the skin dryness (xeroderma) accompanying diabetes, and the disruption of the circadian rhythm was suggested as a possible mechanism through which STZ-induced diabetes contributes to AQP3 downregulation [76]. This evidence concerns the gene AQP3 and diabetes mellitus.