HIC1 and choriocarcinoma: Moreover, choriocarcinoma is characterized by overexpression of p53 and MDM2, along with overexpression of other genes (i.e., NECC1, epidermal growth factor receptor, DOC-2/hDab2, Ras GTPase-activating protein, E-cadherin, HIC-1, p16 and TIMP3) or downregulation via hypermethylation, with no evidence of somatic mutation [91].