Taken together, our results evidence that menthone inhalation may improve airway allergic inflammation, mucin overproduction, eosinophils infiltration, Th1/Th2 immune balance, and relative expression levels of particular receptor genes related to allergic inflammation of the lungs and airways in the allergic asthmatic mice by regulating local and systemic immune responses in allergic asthma. This evidence concerns the gene MUC5AC and allergic asthma.