In addition, AdipoRon, an adiponectin receptor agonist, reduced ceramide levels by activating aCDase activity and normalized the ceramide/S1P ratio in podocyte [298] and GECs [43], ameliorating apoptosis of these cells in DN and ROS-induced endothelial dysfunction in arterioles from patients with coronary artery disease [281]. This evidence concerns the gene ASAH1 and liver dysplastic nodule.