In a model of hypertensive CKD with angiotensin II (Ang II) infusion, where ROS is involved, renal hypoxia, hypertension, proteinuria and fibrosis were more severe in Ang II-infused erythrocyte-specific SphK1 knockout (eSphK1−/−) mice compared with controls [273]. This evidence concerns the gene AGT and Hypertension.