In support of this, expression of proinflammatory markers (Cxcl2, Tlr4, MCP-1, Pcna, and Col3a1) was increased in the kidneys of wild type and Sphk1−/− mice but not in Sphk2−/− mice, suggesting a protective effect of SphK1 on renal inflammation [259]. The gene discussed is SPHK1; the disease is inflammatory response.