PTEN and rheumatoid arthritis: In addition, we observed the enrichment of hsa-miR-26a-5p and hsa-miR-338-5p, which have previously been shown to induce proliferation, viability, and invasion of fibroblast-like synoviocytes in RA via the regulation of the PTEN/PI3K/AKT pathway [52] and the NFAT5 transcription factor [53], respectively.