The most frequent translocations reported in ALK-RCC patients are the fusion of the vinculin (VCL) and ALK, typically in young patients with the sickle cell trait [27], the TPM3–ALK and EML4–ALK fusions in tumors characterized by papillary, solid, and mucinous cribriform components. The gene discussed is VCL; the disease is renal cell carcinoma.