ANGPTL4 and obesity due to melanocortin 4 receptor deficiency: Concerning the impact of ANGPTL4 on the liver, it was recently suggested that the specific depletion of ANGPTL4 in hepatocytes protects against diet-induced obesity and the development of hepatic steatosis [95], while hepatocytes exposure to dexamethasone triggers an ANGPTL4-dependent de novo lipogenesis and TG synthesis [96].