FGF21 and familial pancreatic carcinoma: Indeed, while two studies have suggested that FGF21 protect from NASH to HCC transition and development [141,142], as well as from prostate and pancreatic cancer development [143,144], other studies support an oncogenic role of FGF21 in various other cancers, including thyroid [145], lung [146] and colorectal [147] cancers.