Finally, in silico analyses were performed to evaluate the mRNA expression of these hepatokines in publicly available transcriptomic datasets (Gene Expression Omnibus (GEO) datasets) of hepatic tissues from mice fed a high fat-containing diet for different time periods (9 and 12 weeks), in steatotic MAT1A knockout mice (Figure S4A–C), or in the livers of human cohorts of patients suffering from obesity, steatosis, NASH and/or T2D (Figure S4D–G and Figure S4D–F). Here, MAT1A is linked to type 2 diabetes mellitus.