LECT2 and obesity due to melanocortin 4 receptor deficiency: In contrast, while the expression of Fetub and Lect2 ws found to be decreased in LPTENKO mice, these hepatokines are frequently upregulated in mouse models and patients with obesity, steatosis and IR (Figure 4, Figure S4 and Table S7), supporting a potential important role for these hepatokines in LPTENKO mice.