Together, these data suggest that the deregulated expression of Ahsg, Angptl4, Fetub, Fgf21 and Lect2 may be highly relevant in mediating muscle insulin hypersensitivity and decrease adiposity in LPTENKO mice, therefore highlighting these hepatokines as important modulators of insulin sensitivity, steatosis and obesity in both rodents and humans. The gene discussed is FGF21; the disease is obesity due to melanocortin 4 receptor deficiency.