IGFBP1 and neoplasm: Among the other hepatokines investigated in our study, high levels of AHSG [148,149,150], IGFBP1 [151,152,153] and IGFBP-2 [154,155,156] are found in the serum and HCC tissues of patients, whereas LECT2 expression is usually decreased and appears to behave as a tumour suppressor under the control of beta-catenin in the liver [101,157,158,159].