TLR4 and obesity due to melanocortin 4 receptor deficiency: MiR883b-5p, which is upregulated by APN and lowered in obesity, showed an inhibitory effect on lipopolysaccharide (LPS)-binding protein and Toll-like receptor 4 (TLR4) signaling, thus acting as an important mediator of the anti-inflammatory activity of this adipokine [230].