As a salient feature of this study, we demonstrated that DEHP upregulated the expression of N-cadherin and key stemness markers, including Sox2, Nanog, Oct4, and Klf4, in human endometrial epithelial cells, indicating that DEHP alters their stemness status, thereby contributing to the pathogenesis of endometriosis. This evidence concerns the gene CDH2 and endometriosis.