Human IL-8 (C–X–C motif chemokine ligand 8, CXCL-8), monocyte chemoattractant protein-1 (MCP-1; C–C motif chemokine ligand 2, CCL2), and regulated upon activation, normal T-cell expressed and secreted (RANTES; C–C motif chemokine ligand 5, CCL5) are central proinflammatory chemokines which serve as important mediators of inflammation and immunological processes in several inflammatory and immune diseases. This evidence concerns the gene CXCL8 and immune system disorder.