APP and glaucoma: Using the glaucoma model by laser photocoagulation of the trabecular meshwork in Sprague–Dawley rats, they identified an increase in APP immunofluorescence in the ONH, which happened as soon as 8 h after induction of IOP rise, peaked at 24 h, persisted at 3 and 7 days, but was barely detected at 14 days after surgery.