Importantly, in the mouse, the invalidation of any of the four pore-forming α subunits gene, CatSper1–4, or the auxiliary CatSperδ subunit gene was shown to cause asthenozoospermia by abrogating Ca2+ influxes and hyperactivated motility [53,60,61,62]. The gene discussed is CATSPERD; the disease is Reduced sperm motility.